A UUID (Universally Unique Identifier) is a 128-bit value used to identify information without requiring a central authority to hand out the ids. “GUID” (Globally Unique Identifier) is the same thing under a different name, coined by Microsoft — the two terms are used interchangeably.
A UUID is conventionally written as 32 hexadecimal digits split into five groups by hyphens, in the pattern 8-4-4-4-12, for example f47ac10b-58cc-4372-a567-0e02b2c3d479. That structure isn't arbitrary — certain digits encode the UUID's version and variant, which is how software can tell a v4 UUID apart from a v5 one just by looking at it.
Auto-incrementing integers work fine inside a single database, but they break down the moment you have more than one system generating ids independently — two services can hand out the same number, and merging datasets from different sources creates collisions. UUIDs solve this by being generated independently, without coordination, while still being collision-resistant. Any two systems, anywhere, generating a v4 UUID at the same moment have a practically zero chance of producing the same value.
Need to generate some? The GUID / UUID Generator on this site creates v1, v4, and v5 identifiers in bulk, entirely in your browser — nothing is sent to a server.